IL37 dampens the IL1β-induced catabolic status of human OA chondrocytes
نویسندگان
چکیده
منابع مشابه
Effects of hypoxia on anabolic and catabolic gene expression and DNA methylation in OA chondrocytes
BACKGROUND Cartilage is an avascular and aneural tissue. Chondrocytes thrive in this restricted environment of low oxygen tension and poor nutrient availability which has led to suggestions that hypoxia may be a protective mechanism against the development of osteoarthritis (OA). There is also a growing body of evidence to support the role of epigenetic factors in the pathogenesis of OA. Howeve...
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Baicalein is a flavone compound isolated from Scutellaria baicalensis Georgi (Huang Qin) which exerts multiple biological effects including anti-inflammatory, anti-apoptotic and anti-tumor. However, there is little known about the effects of baicalein on cathepsins and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) in osteoarthritis (OA). In the present study, we invest...
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Voltage-sensitive calcium channels (VSCC) regulate cellular calcium influx, one of the earliest responses to mechanical stimulation in osteoblasts. Here, we postulate that T-type VSCCs play an essential role in bone mechanical response to load and participate in events leading to the pathology of load-induced OA. Repetitive mechanical insult was used to induce OA in Cav3.2 T-VSCC null and wild-...
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Osteoarthritis (OA) affects a large number of patients; however, human umbilical cord stem cells exhibit therapeutic potential for treating OA. The aim of the present study was to explore the interaction between human umbilical cord stem cells and degenerated chondrocytes, and the therapeutic potential of human umbilical cord stem cells on degenerated chondrocytes. Human umbilical cord‑derived ...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2016
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/kew411